Product Details
DESCRIPTION
Insulin detemir is a long-acting recombinant human insulin analog produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae followed by chemical modification.
Insulin detemir differs from human insulin in that the amino acid threonine in position B30 has been omitted, and a C14 fatty acid chain has been attached to the amino acid B29. Insulin detemir has a molecular formula of C267H402O76N64S6 and a molecular weight of 5.917 kDa. It has the following structure:
Insulin detemir injection is a clear, colorless, aqueous, neutral sterile solution
for subcutaneous use. Each milliliter of INSULIN DETERMIR contains 100 units insulin detemir, dibasic sodium phosphate (0.71 mg), glycerin (16 mg), metacresol (2.06 mg), phenol (1.8 mg), sodium chloride (1.17 mg), zinc (65.4 mcg), and Water for Injection, USP. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH. INSULIN DETERMIR has a pH of approximately 7.4.
Mechanism of Action
The primary activity of insulin, including INSULIN DETERMIR, is regulation of glucose metabolism. Insulins and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis.
Pharmacodynamics
Insulin detemir is a soluble, long-acting basal human insulin analog with up to a 24-hour duration of action. The pharmacodynamic profile of INSULIN DETEMIR is relatively constant with no pronounced peak. The duration of action of INSULIN DETEMIR is mediated by slowed systemic absorption of insulin detemir molecules from the injection site due to self-association of the drug molecules. In addition, the distribution of insulin detemir to peripheral target tissues is slowed because of binding to albumin.
Figure 2 shows results from a study in patients with type 1 diabetes conducted for a maximum of 24 hours after the subcutaneous injection of INSULIN DETEMIR. The mean time between injection and the end of pharmacological effect for insulin detemir ranged from 7.6 hours to >24 hours (24 hours was the end of the observation period).
Name: Insulin detemir
Insulin detemir is a prescription medicine used to treat the symptoms of Type I or II Diabetes Mellitus. Insulin detemir may be used alone or with other medications.
Dosage: Injection
Specification
3ml: 300units
Indications
Insulin detemir is indicated to improve glycemic control in adults and children with diabetes mellitus.
Social Responsibility
"Take gene engineering as orientation, Render service to human health", is the prospect placed by Mr. Tan Jiazhen (C.C.Tan) on Jiuyuan, who was a leading Chinese scientist in genetics and famous biological scientist, and it is also the final goal of Jiuyuan. In the recent two decades, Jiuyuan has been making its contribution to social programs.
The sales network covers more than 30 provinces and cities across the country,
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Company Honor
Zhejiang province per mu benefit leading enterprises
Gene-engineering New Drug R&D Technology and Service Sub-platform
Provincial Post-doctoral Scientific Research Working Center
Excellent industrial products in Zhejiang Province
Hangzhou Academician Expert Working Center
Hangzhou Top Ten New High-tech Enterprise
Zhejiang Green Enterprise
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